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Validation of numerical flow simulations against in vitro phantom measurements in different type B aortic dissection scenarios.

TitleValidation of numerical flow simulations against in vitro phantom measurements in different type B aortic dissection scenarios.
Publication TypeJournal Article
Year of Publication2015
AuthorsSoudah, E, Rudenick, P, Bordone, M, Bijnens, B, Garcia-Dorado, D, Evangelista, A, Onate, E
JournalComput Methods Biomech Biomed Engin
Volume18
Issue8
Pagination805-15
Date Published2015
ISSN1476-8259
KeywordsAneurysm, Dissecting, Aortic Aneurysm, Computer Simulation, Hemodynamics, Humans, Models, Cardiovascular, Phantoms, Imaging
Abstract

An aortic dissection (AD) is a serious condition defined by the splitting of the arterial wall, thus generating a secondary lumen [the false lumen (FL)]. Its management, treatment and follow-up are clinical challenges due to the progressive aortic dilatation and potentially severe complications during follow-up. It is well known that the direction and rate of dilatation of the artery wall depend on haemodynamic parameters such as the local velocity profiles, intra-luminal pressures and resultant wall stresses. These factors act on the FL and true lumen, triggering remodelling and clinical worsening. In this study, we aimed to validate a computational fluid dynamic (CFD) tool for the haemodynamic characterisation of chronic (type B) ADs. We validated the numerical results, for several dissection geometries, with experimental data obtained from a previous in vitro study performed on idealised dissected physical models. We found a good correlation between CFD simulations and experimental measurements as long as the tear size was large enough so that the effect of the wall compliance was negligible.

DOI10.1080/10255842.2013.847095
Alternate JournalComput Methods Biomech Biomed Engin
PubMed ID24156535