|Title||Validation of numerical flow simulations against in vitro phantom measurements in different type B aortic dissection scenarios.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Soudah, E, Rudenick, P, Bordone, M, Bijnens, B, Garcia-Dorado, D, Evangelista, A, Onate, E|
|Journal||Comput Methods Biomech Biomed Engin|
|Keywords||Aneurysm, Dissecting, Aortic Aneurysm, Computer Simulation, Hemodynamics, Humans, Models, Cardiovascular, Phantoms, Imaging|
An aortic dissection (AD) is a serious condition defined by the splitting of the arterial wall, thus generating a secondary lumen [the false lumen (FL)]. Its management, treatment and follow-up are clinical challenges due to the progressive aortic dilatation and potentially severe complications during follow-up. It is well known that the direction and rate of dilatation of the artery wall depend on haemodynamic parameters such as the local velocity profiles, intra-luminal pressures and resultant wall stresses. These factors act on the FL and true lumen, triggering remodelling and clinical worsening. In this study, we aimed to validate a computational fluid dynamic (CFD) tool for the haemodynamic characterisation of chronic (type B) ADs. We validated the numerical results, for several dissection geometries, with experimental data obtained from a previous in vitro study performed on idealised dissected physical models. We found a good correlation between CFD simulations and experimental measurements as long as the tear size was large enough so that the effect of the wall compliance was negligible.
|Alternate Journal||Comput Methods Biomech Biomed Engin|