You are here


Fri, 29/01/2016 - 09:56

Information and registration:

This Summer School provides a thorough overview and hands-on experience in state-of-the-art Virtual Physiological Human (VPH) research. The key concepts of this methodological and technological framework will be presented using illustrative cases and enriched with hands-on analysis under supervision of the experts.

The School is jointly organised by the Philips - UPF CardioFunXion Marie Curie European Industrial Doctorate Program and The Virtual Physiological Human Institute, and the support of the Spanish Network of Excellence in Biomechanics.

Fri, 04/09/2015 - 11:25


Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood-flow redistribution in order to maintain perfusion to the brain. However, some hemodynamic parameters that might be more directly related to staging of the disease cannot be measured non-invasively in clinical practice. For this, we developed a patient-specific model of the fetal circulation to estimate vascular properties of each individual. A lumped model of the fetal circulation was developed and personalized using measured echographic data from 37 normal and IUGR fetuses to automatically estimate model-based parameters. The estimated model-based placental and brain resistances were respectively increased and reduced in IUGR fetuses while placental compliance was increased in IUGR fetus. Umbilical and middle cerebral arteries PIs were most associated with both placental resistance and compliance, while uterine artery PI was more associated with the placental compliance. The logistic regression analysis showed that the model added significant information to the traditional analysis of Doppler waveforms for predicting adverse outcome in IUGR. The proposed patient-specific computational model seems to be a good approach to assess hemodynamic parameters than cannot be measured clinically.


Patricia Garcia-Canadilla, Fatima Crispi, Monica Cruz-Lemini, Stefania Triunfo, Alfons Nadal, Brenda Valenzuela-Alcaraz, Paula A. Rudenick, Eduard Gratacosa and  Bart H. Bijnens


Tue, 14/07/2015 - 12:01

We congratulate Dr. Patricia García Cañadilla, who defended her dissertation on July 2nd. Well done Patricia ;).

Tue, 02/06/2015 - 18:15

Authors: Rubén Cárdenes, Rafael Sebastian, David Soto-Iglesias, Antonio Berruezo, Oscar Camara

The electrical activation of the heart is a complex physiological process that is essential for the understanding of several cardiac dysfunctions, such as ventricular tachycardia (VT). Nowadays, patient-specific activation times on ventricular chambers can be estimated from electro-anatomical maps, providing crucial information to clinicians for guiding cardiac radio-frequency ablation treatment. However, some relevant electrical pathways such as those of the Purkinje system are very difficult to interpret from these maps due to sparsity of data and the limited spatial resolution of the system. We present here a novel method to estimate these fast electrical pathways from the local activations maps (LATs) obtained from electro-anatomical maps. The location of Purkinje-myocardial junctions (PMJs) is estimated considering them as critical points of a distance map defined by the activation maps, and then minimal cost geodesic paths are computed on the ventricular surface between the detected junctions. Experiments to validate the proposed method have been carried out in simplified and realistic simulated data, showing good performance on recovering the main characteristics of simulated Purkinje networks (e.g. PMJs). A feasibility study with real cases of fascicular VT was also performed, showing promising results.