Intrauterine growth restriction is a disease that affects about 10% of the pregnancies leading to important structural and functional changes in the heart. These changes persist postnatally and have been associated with an increased risk of cardiovascular diseases in adulthood. Moreover there also changes in the structure and function at cellular and subcellular level. However how these changes affect the global function of the heart need to be further investigated. A 3D electromechanical model of the cardiomyocyte would be a useful tool to study the local behavior of the heart and to relate it with the global performance of the whole organ. In this presentation I’m going to talk about the study and modeling of the cardiomyocyte, and its applicability to study the cellular and subcellular changes observed in IUGR.