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Paula Andrea Rudenick published an article about Assessment of Wall Elasticity Variations on Intraluminal Haemodynamics in Descending Aortic Dissections Using a Lumped-Parameter Model

 

Fig 1. Proposed experimental representation of a clinical aortic dissection and its equivalent lumped-parameter model.

Abstract:
 
Descending aortic dissection (DAD) is associated with high morbidity and mortality rates. Aortic wall stiffness is a variable often altered in DAD patients and potentially involved in long-term outcome. However, its relevance is still mostly unknown. To gain more detailed knowledge of how wall elasticity (compliance) might influence intraluminal haemodynamics in DAD, a lumped-parameter model was developed based on experimental data from a pulsatile hydraulic circuit and validated for 8 clinical scenarios. Next, the variations of intraluminal pressures and flows were assessed as a function of wall elasticity.

In comparison with the most rigid-wall case, an increase in elasticity to physiological values was associated with a decrease in systolic and increase in diastolic pressures of up to 33% and 63% respectively, with a subsequent decrease in the pressure wave amplitude of up to 86%. Moreover, it was related to an increase in multidirectional intraluminal flows and transition of behaviour as 2 parallel vessels towards a vessel with a side-chamber. The model supports the extremely important role of wall elasticity as determinant of intraluminal pressures and flow patterns for DAD, and thus, the relevance of considering it during clinical assessment and computational modelling of the disease.

Fig 1. Proposed experimental representation of a clinical aortic dissection and its equivalent lumped-parameter model.

(a) Clinical appearance of a descending aortic dissection in the longitudinal plane. Transversal plane showing the distinction between TL and FL (Bottom right) (b-c) Proposed anatomic representation of a descending aortic dissection. Longitudinal diagram of the experimental model (b) and cross-sectional plane of the dissected segment (c). (d) Schema of the lumped-parameter model. The dissected region was modelled as two parallel compartments communicated by resistances (rigid tears). Dashed lines enclose the different compartments of the model: Proximal tear (PT), false lumen (FL), true lumen (TL), distal tear (DT) and peripheral (PH) bed.

Citation: Rudenick PA, Bijnens BH, Segers P, García-Dorado D, Evangelista A (2015) Assessment of Wall Elasticity Variations on Intraluminal Haemodynamics in Descending Aortic Dissections Using a Lumped-Parameter Model. PLoS ONE 10(4): e0124011. doi:10.1371/journal.pone.0124011