Some members of PhySense have been collaborating during the last months with researchers at the Universidad de Zaragoza (the BSICOS group led by Prof. Pablo Laguna) and together with clinicians of the Arrhythmia Unit at the Department of Cardiology at Hospital Clínic de Barcelona (led by Dr. Antonio Berruezo) for the development of advanced signal processing techniques applied to electro-anatomical data. This collaboration has recently produced a journal paper that has just appeared in the IEEE Transactions on Biomedical Engineering journal, entitled "A Wavelet-Based Electrogram Onset Delineator for Automatic Ventricular Activation Mapping": http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6834811
In this work, Alcaine et al. present an automatic delineation of the earliest activation area in electro-anatomical mapping (EAM) data from focal tachycardia patients, which usually is a manual time-consuming and experience-dependent task. Data from 10 patients were processed and results were compared with manual annotations performed during (stress condition, on-procedure) and after (non-stress condition, off-procedure) the clinical procedure by expert technicians. The automatic annotations showed good correlation with the reference data, obtaining an average error of 2.1 (+-) 10.9 ms which is in the order of the manual ones in stress conditions, suggesting that the proposed automatic technique could be incorporated into the EAM systems to considerably reduce processing time during this type of interventions.
Example of activation map corresponding to the right ventricle shown in anterior-posterior view including a zoom view (white square) of the earliest activation area: a) LATs from the on-procedure annotation set, b) obtained LATs with the automatic algorithm presented in this paper and c) using the “averaged off-procedure” LATs annotation considered as evaluation reference. LATs are shown in 10 ms isochrone areas color-coded from red (earlier) to pink (later) referenced to the QRS complex. White crosses indicate the acquired mapping points and pink spheres pointed by white arrows indicate the effective ablation point/s that terminated the arrhythmia.